Update on Intravenous Fibrinolytic Therapy for Acute Myocardial Infarction

Intracerebral hemorrhage after fibrinolytic therapy for acute myocardial infarction.

BACKGROUND AND PURPOSE Intracerebral hematoma may complicate treatment of acute myocardial infarction in patients treated with fibrinolytic agents. We studied the clinical presentation and computed tomographic characteristics. METHODS We studied eight patients with lobar intracerebral hematomas after fibrinolytic treatment of acute coronary occlusion. All patients had electrocardiographic and...

Is transfer for primary angioplasty better than on-site fibrinolytic therapy for acute myocardial infarction?

Intravenous magnesium for acute myocardial infarction.

BACKGROUND Mortality and morbidity from acute myocardial infarction (AMI) remain high. Intravenous magnesium started early after the onset of AMI is thought to be a promising adjuvant treatment. Conflicting results from earlier trials and meta-analyses warrant a systematic review of available evidence. OBJECTIVES To examine the effect of intravenous magnesium versus placebo on early mortality...

Fibrinolytic treatment for elderly patients with acute myocardial infarction.

Fibrinolytic treatment is the standard of care for eligible patients presenting early with acute ST segment elevation myocardial infarction (MI) to hospitals where rapid triage to primary angioplasty is unavailable. Although fibrinolytic treatment of elderly patients is generally accepted, a recent paper raised questions about its safety and efficacy. In this editorial, we will review the relev...

Neurologic assessment after fibrinolytic therapy for myocardial infarction.

in the neuroscience intensive care unit at the University of Virginia Health System in Charlottesville. properties of the fibrinolytic agent and the impact of adjuvant therapies such as antiplatelet and anticoagulant agents must also be considered. Tenecteplase is a variant of tissue plasminogen activator (t-PA) that is genetically engineered to have increased fibrin specificity, a longer half-...